RNA Sequencing of Discarded Tracheal Stenosis Tissue to Characterize Cellular and Molecular Pathogenesis

Recruiting now

Conditions studied: Tracheal Stenosis, Subglottic Stenosis

In brief

Benign tracheal stenosis is a rare but potentially life-threatening condition, typically resulting from fibroinflammatory scarring. It can be secondary to iatrogenic etiologies such as intubation or tracheostomy , as well as autoimmune diseases and being idiopathic. Patients typically undergoes endoscopic or surgical interventions to open up the airways. This project will analyze resected or biopsied tissue from patients with benign tracheal stenosis to define disease-specific RNA expression profiles.

Key facts

Study ID

NCT07258784

Run by

University of Maryland, Baltimore

People needed

10

Starts

2025-09-11

Expected to finish

2026-12-31

Last updated by the study team

2025-12-02

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with benign tracheal stenosis

You may not qualify if…

• Malignancy. active infection

Where it is running

• University of Maryland — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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