Generation of Endometrial Carcinoma Organoids
Recruiting now
Conditions studied: Endometrial Cancer
In brief
A prospective pilot genetic study to evaluate the feasibility of generating organoids from endometrial tumor tissue collected during surgery, performed according to standard clinical practice. Samples will be collected from collaborating extramural facilities, with the aim of analyzing the impact of transport on tissue viability and the success of organoid culture. This study is for exploratory purposes only, without altering the diagnostic and therapeutic pathways of the participants.
Key facts
- Study ID
- NCT07258186
- Run by
- Regina Elena Cancer Institute
- People needed
- 20
- Starts
- 2025-03-23
- Expected to finish
- 2028-09-23
- Last updated by the study team
- 2025-12-02
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Age >18 years;
- Patients with a histological diagnosis of: endometrial cancer, endometrioid histology, any stage of disease (FIGO I-IV), recurrence/metastasis from endometrial endometrioid cancer, and candidates for surgery and/or hysterectomy;
- Written informed consent (study participation and data processing) must be obtained in person and/or through a legal representative/guardian/support administrator/witness, before any study-specific procedure is performed.
You may not qualify if…
- Comorbidities not controlled with adequate medical therapy;
- Endometrial cavity infections (pyometra);
- Synchronous tumors;
- Neoadjuvant treatments;
- Previous radiation treatments to the pelvic region.
Where it is running
- IRCCS National Cancer Institute "Regina Elena" — Roma, Roma, Italy (enrolling)
Full record on ClinicalTrials.gov
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