Efficacy and Safety of a Single Dose of Emodepside Compared to a Single Dose of Albendazole in Adolescents and Adults Infected With Trichuris Incognita
Starting soon · Phase 2
Conditions studied: Trichuris Infection
In brief
The purpose of this clinical trial is to compare the efficacy and safety of emodepside with the standard treatment, albendazole, in adolescents (12 years and older) and adults infected with Trichuris incognita.
Key facts
- Study ID
- NCT07258173
- Run by
- Jennifer Keiser
- People needed
- 100
- Starts
- 2026-05-15
- Expected to finish
- 2026-09-15
- Last updated by the study team
- 2026-05-08
Who can join
Age: 12 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged 12 years and above.
- Written informed consent signed by participant and, in the case of minors, parents/caregivers.
- Agree to comply with study procedures, including provision of two stool samples at the beginning (screening) and at follow-up assessment 14-21 days after treatment.
- Having at least two slides of the quadruple Kato-Katz thick smears positive for Trichuris incognita and infection intensities of at least 48 eggs per gram (EPG).
- Willing to be examined by a study physician prior to treatment.
You may not qualify if…
- Presence or signs of major systemic illnesses, e.g. body temperature ≥ 38 °C, severe anemia (Hb below 80g/l) upon initial clinical assessment etc.
- History of severe acute or unmanaged severe chronic disease (i.e., condition is not as therapeutically controlled as necessary).
- Positive malaria rapid diagnostic test (RDT) and temperature ≥ 38 °C.
- Abnormal liver and renal function assessed by biochemical blood-based analyses.
- Recent use of anthelmintic drugs (in the 4 weeks before treatment).
- Known allergy to study medications and formulations (i.e. albendazole and emodepside).
- Prescribed or taking medication with known contraindication to or interaction with study drugs.
- Participating in other clinical trials during the study period.
- Pregnancy or breastfeeding.
Full record on ClinicalTrials.gov
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