A Study of GC203 TIL in Advanced Solid Tumors (NF)
Recruiting now · Phase 1
Conditions studied: Solid Tumors, Adult
In brief
This study is a prospective, open-label, single-arm clinical trial aimed at evaluating the safety and efficacy of GC203 TIL therapy in treating malignant solid tumors that have failed standard treatment.
Key facts
- Study ID
- NCT07256756
- Run by
- Shanghai Juncell Therapeutics
- People needed
- 8
- Starts
- 2026-01-30
- Expected to finish
- 2028-11-30
- Last updated by the study team
- 2026-08-05
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- have one the tumor resection for gene-edited GC203 TIL production and successfully produced；
- Age: 18 years to 75years;
- Histologically diagnosed as solid tumor;
- Expected life-span more than 3 months;
- ECOG score 0-1;
- Test subjects have failed standard treatment regimens, and be willing to receive engineered GC203 TIL therapy;
- At least 1 evaluable tumor lesion;
You may not qualify if…
- with other malignant tumors,except for the malignancies that have been cured, have been inactive for ≥5 years prior to study inclusion and have a very low risk of recurrence; Non-melanoma skin cancer or malignant lentigo with adequate treatment and no evidence of disease recurrence; Carcinoma in situ with adequate treatment and no evidence of disease recurrence;
- Need glucocorticoid treatment, and daily dose of Prednisone greater than 10mg(or equivalent doses of hormones) or outoimmune diseases requiring immunomodulatory treatment;
- Breathe indoor air in a quiet state, and the oxygen saturation of finger pulse is < 95%;
- Human immunodeficiency virus (HIV) infection or anti-HIV antibody positive, active HBV or HCV infection (HBsAg positive and/or anti-HCV positive), syphilis infection or Treponema pallidum antibody positive;
- Significant cardiovascular anomalies
Where it is running
- Shenzhen Hospital of Southern Medical University — Shenzhen, China (enrolling)
Full record on ClinicalTrials.gov
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