Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication

Recruiting now · Not applicable

Conditions studied: Endodontically Retard Teeth, Periapical Radiolucency

In brief

Successful endodontic treatment and a predictable outcome can only be achieved by effective root canal debridement, irrigation, and elimination of microorganisms . The outcome of endodontic treatment performed in controlled clinical environment has demonstrated success rate around 90%. In certain cases, endodontic treatment may fail, one of the most common reasons is inability to eliminate microorganisms from the root canal. When non-surgical root canal therapy fails, the treatment options include orthograde re-treatment, periradicular surgery, or extraction. Simvastatin (SIM) is a drug used primarily to treat hyperlipidemia and protect against cardiovascular diseases. It has been shown to possess pleiotropic effects such as antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and bone-forming properties . The side chain of this material has a single methyl group. It inhibits hydroxymethyl glutarylcoenzyme reductase that prevents endogenous cholesterol synthesis

Key facts

Study ID

NCT07256561

Run by

Hadeer Maher Mostafa Mohamed

People needed

54

Starts

2025-08-10

Expected to finish

2026-08-10

Last updated by the study team

2025-12-01

Who can join

Age: 20 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients had anon contributory medical history.
• Patients of age categories between 20 to 40 years old, with no physical disability or psychological problems.
• Single rooted teeth with type I root canal anatomy.
• Symptomatic cases of failed endodontic treatment with radiographic evidence of periapical bone loss, and the lesion size ranging from 2mm up to 8mm.

You may not qualify if…

• Patients with known sensitivity to the pharmaceutical used in this trial
• Patients with former endodontic mishaps (as ledges, transportations, perforations or separated instruments)
• Non restorable teeth
• Presence of an associated sinus tract.
• Advanced periodontal involvement
• Teeth representing root fracture.
• Pregnant women

Where it is running

• Faculty of Dental Medicine for Girls, Al-Azhar University — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

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