Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma
Recruiting now
Conditions studied: Scleroderma
In brief
Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.
Key facts
- Study ID
- NCT07256418
- Run by
- Centre Hospitalier Universitaire Dijon
- People needed
- 60
- Starts
- 2026-01-26
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2026-01-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- FOR PATIENTS WITH SCLERODERMA :
- Person who has given written consent
- Person with systemic scleroderma
- FOR CONTROL PARTICIPANTS :
- Person who has given written consent
- Person undergoing plastic, cosmetic and reconstructive surgery
You may not qualify if…
- FOR PATIENTS WITH SCLERODERMA :
- Person not affiliated to or not benefiting from a social security scheme
- Person subject to a legal protection measure (curatorship, guardianship)
- Person subject to a legal protection measure
- An adult who is incapable or unable to give consent
- Minors
- FOR CONTROLLED PARTICIPANTS :
- Person suffering from a chronic disease or under chronic treatment for autoimmune, inflammatory or dermatological diseases
- Person not affiliated to or not benefiting from a social security scheme
- Person under legal protection (curatorship, guardianship)
- Person subject to a legal protection measure
- An adult who is incapable or unable to give consent
- Minors
Where it is running
- CHU Dijon Bourgogne — Dijon, France (enrolling)
Full record on ClinicalTrials.gov
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