Cabergoline & Letrozole Versus Letrozole in Ovulation Induction in PCOS
Recruiting now · Not applicable
Conditions studied: PCOS
In brief
Does combined Cabergoline and letrozole increase ovulation rate What medical problems do participants have when taking drug Cabergoline and Letrozole ? Researchers will compare drug combination of Cabergoline and letrozole to letrozole alone to see combined cabergoline and letrozole works better as ovulation induction. Participants will: experimental group will receive Cabergoline and Letrozole comparator group will receive letrozole alone TVS Monitoring will be done for 3 cycle for ovarian response
Key facts
- Study ID
- NCT07255911
- Run by
- Mst.Sumyara Khatun
- People needed
- 72
- Starts
- 2025-02-07
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2025-12-16
Who can join
Age: 18 and older, up to 35. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- PCOS patients diagnosed according to Rotterdam criteria.
- Age: 18-35 years.
- Primary or secondary subfertility.
- Selected for ovulation induction.
You may not qualify if…
- Women suffered from PCOS like symptom ex. Late onset congenital adrenal hyperplasia, Cushing syndrome.
- Serum prolactin (more than 50 ng/ml) (Kyritsi et al., 2018).
- Male factor infertility.
- Women with other infertility factors (endometriosis, PID,uterine \& tubal causes of infertility).
- Uncontrolled Medical disease (DM, HTN, kidney disease, liver disease).
- History of hypersensitivity to cabergoline \& letrozole.
- Thyroid dysfunction ( serum TSH ≥5mIU/L)
- BMI:< 18.5 kg/m2 and ≥30 kg/m2.
- Patients on metformin therapy.
- Patient on antiemetic like Domperidone metoclopramide, antipsychotic drug like haloperidol and risperidone, tricyclic antidepressant like amitriptyline, clomipramine, antihypertensive like verapamil, methyldopa, reserpine.
Where it is running
- Bangladesh Medical University — Dhaka, Shahbag, Bangladesh (enrolling)
Full record on ClinicalTrials.gov
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