A Clinical Trial Testing the Safety of Pumitamig (an Investigational Drug) and How Well it Works When Combined With Chemotherapy for People Who Have Not Been Treated Yet for Pancreatic Cancer
Recruiting now · Phase 2
Conditions studied: Pancreatic Ductal Adenocarcinoma (PDAC)
In brief
This study will enroll adults with confirmed metastatic pancreatic ductal adenocarcinoma (PDAC, systemic PDAC treatment naïve), Eastern Cooperative Oncology Group performance status (ECOG PS) 0-1, and adequate organ function. Participants will receive pumitamig (also known as BNT327, BMS-986545, or PM8002) in combination with chemotherapy.
Key facts
- Study ID
- NCT07255404
- Run by
- BioNTech SE
- People needed
- 105
- Starts
- 2025-12-04
- Expected to finish
- 2028-08-01
- Last updated by the study team
- 2026-07-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, China (enrolling)
- Henan Cancer Hospital — Zhengzhou, China (enrolling)
- Tsinghua Changgung Hospital — Beijing, China (enrolling)
- Sichuan Cancer Hospital — Chengdu, China (enrolling)
- Sun Yat-sen Memorial Hospital, Sun Yat-sen University — Guangzhou, China (enrolling)
- Zhejiang Provincial People's Hospital — Hangzhou, China (enrolling)
- Yunnan Cancer Hospital — Kunming, China (enrolling)
- The First Affiliated Hospital of Nanchang University — Nanchang, China (enrolling)
- The Affiliated Cancer Hospital of Guangxi Medical University — Nanning, China (enrolling)
- Huashan Hospital, Fudan University — Shanghai, China (enrolling)
- Fudan University Shanghai Cancer Center — Shanghai, China (enrolling)
- The First Affiliated Hospital of China Medical University — Shenyang, China (enrolling)
- Peninsula & South Eastern Haematology and Oncology Group — Frankston, Australia (enrolling)
- GenesisCare — Saint Leonards, Australia (enrolling)
- Flinder's Medical Centre — Bedford Park, Australia
- Pindara Private Hospital — Benowa, Australia
- Jilin Cancer Hospital — Changchun, China
- The Alfred Hospital — Melbourne, Australia
- St Vincent's Hospital — Melbourne, Australia
- One Clinical Research — Mount Pleasant, Australia
- Shandong University Cancer Hospital — Jinan, China
- Sunshine Coast Private Hospital — Sunshine Coast, Australia
- Westmead Hospital — Sydney, Australia
- Zhongshan Hospital Affiliated with Dalian University — Dalian, China
Full record on ClinicalTrials.gov
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