Use of Vassopresin in Septic Shock Prospective Multicenter Observational Study With Medication
Recruiting now
Conditions studied: Septic Shock
In brief
The aim of this observational study is to examine real-world clinical practice regarding the use of vasopressin as a second-line vasopressor in adult patients admitted to Intensive Care Units (ICUs) with septic shock. The study focuses on critically ill adults (≥18 years) diagnosed with septic shock and treated with norepinephrine and vasopressin. The main research questions are: * Does early initiation of vasopressin-defined by the norepinephrine dose at the time of introduction-reduce mortality in patients with septic shock? * What is the impact of vasopressin as a second vasopressor on renal function and the progression of organ dysfunction in septic shock patients? Participants will: * Be admitted to an ICU with a diagnosis of septic shock. * Receive vasopressin as an adjunct to norepinephrine for hemodynamic support. * Be monitored daily throughout their ICU stay, with data collected through a dedicated REDCap system. * Have relevant clinical data pseudonymized and incorporated into the study database for statistical analysis.
Key facts
- Study ID
- NCT07255378
- Run by
- Jamil Cedeño Mora
- People needed
- 1200
- Starts
- 2025-10-01
- Expected to finish
- 2028-01-01
- Last updated by the study team
- 2025-12-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Consorci Sanitari de Terrassa — Terrassa, BARCELONA, Spain (enrolling)
- Hospital Universitario de Getafe — Getafe, Madrid, Spain (enrolling)
- Hospital Universitario La Princesa — Madrid, Madrid, Spain (enrolling)
- Hospital General Universitario Gregorio Marañón — Madrid, Madrid, Spain (enrolling)
- Hospital Universitario Ramón y Cajal — Madrid, Madrid, Spain (enrolling)
- Hospital Universitario Clínico San Carlos — Madrid, Madrid, Spain (enrolling)
- Hospital Universitario Doce de Octubre — Madrid, Madrid, Spain (enrolling)
- Hospital Universitario La Paz — Madrid, Madrid, Spain (enrolling)
- Hospital Universitario Puerta de Hierro — Majadahonda, Madrid, Spain (enrolling)
- Hospital Universitario Rey Juan Carlos — Móstoles, Madrid, Spain (enrolling)
- Hospital Universitario y Politécnico de La Fe — Valencia, Valencia, Spain (enrolling)
- Hospital Universitario Miguel Servet — Zaragoza, ZARAGOZA, Spain (enrolling)
Full record on ClinicalTrials.gov
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