Peripheral Helper T-cells in Common Variable ImmunoDeficiency

Recruiting now · Not applicable

Conditions studied: Common Variable Immunodeficiency

In brief

The aim is to determine whether whether Tph could support non-infectious complications through providing help to pathological B-cells.

Key facts

Study ID

NCT07255157

Run by

University Hospital, Bordeaux

People needed

60

Starts

2026-07-09

Expected to finish

2028-01-01

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female;
• Age ≥ 18 years;
• Standard criteria will be applied to diagnose CVID, specifically requiring: 1) low serum IgG level <5 g/L, combined with low IgM- and/or IgA-isotype concentrations <0.4 g/L or <0.7 g/L, respectively; 2) poor antibody responses to immunization or infection; and 3) exclusion of other defined forms of secondary hypogammaglobulinemias. Patients meeting the definitional criteria for CVID will be included, regardless of the duration of the disease or the treatment received (gammaglobulins substitution or not);
• Being affiliated to health insurance;
• Willing to participate and to sign informed consent.

You may not qualify if…

• Patients on corticosteroids and/or immunosuppressants;
• Patients with a primary immunodeficiency genetically characterized, such as Bruton disease our HyperIgM syndrome;
• Patients with an active chronic infection;
• Pregnant or breastfeeding women;
• Persons deprived of their liberty by a judicial or administrative decision, minors, persons of legal age who are the object of a legal protection measure or unable to express their consent.

Where it is running

• CHU de Bordeaux - service de médecine interne — Pessac, France (enrolling)

Full record on ClinicalTrials.gov

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