CHina Adrenal Venous saMPling InvestigatiON

Recruiting now

Conditions studied: Hyperaldosteronism, Adrenal Venous Sampling, Adrenalectomy

In brief

Primary aldosteronism (PA) is a major cause of secondary hypertension, yet its optimal diagnosis and management remain challenging. This study comprehensively evaluates adrenal venous sampling (AVS), addressing key clinical, technical, and methodological issues, and aims to clarify the relationship between AVS-guided management and long-term clinical and biochemical outcomes to optimize patient care and prognosis.

Key facts

Study ID

NCT07252284

Run by

Chinese Academy of Medical Sciences, Fuwai Hospital

People needed

5000

Starts

2025-05-01

Expected to finish

2029-08-31

Last updated by the study team

2025-11-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with confirmed primary aldosteronism;
• Patients undergoing adrenal venous sampling for subtype classification of primary aldosteronism.

You may not qualify if…

• Severe comorbidity, including stroke, myocardial infarction, heart failure, severe valvular heart disease, liver cirrhosis, and metastatic tumor within the previous 3 months；
• An estimated glomerular filtration rate <45 ml/min/1.73 m2, or serum creatinine >176 μmol/L；
• Patients who refuse adrenalectomy;
• Suspected of having an adrenocortical carcinoma;
• Allergy to contrast agent;
• Pregnant, nursing, or planning to become pregnant

Where it is running

• Chuiyangliu Hospital affiliated to Tsinghua University — Beijing, Beijing Municipality, China (enrolling)
• China-Japan Friendship Hospital — Beijing, Beijing Municipality, China (enrolling)
• Peking University First Hospital — Beijing, Beijing Municipality, China (enrolling)
• Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College — Beijing, Beijing Municipality, China (enrolling)
• Peking University People's Hospital — Beijing, Beijing Municipality, China (enrolling)
• Beijing Luhe Hospital, Capital Medical University — Beijing, Beijing Municipality, China (enrolling)
• Chongqing University Central Hospital — Chongqing, Chongqing Municipality, China (enrolling)
• Chongqing General Hospital — Chongqing, Chongqing Municipality, China (enrolling)
• People's Hospital Affiliated to ChongqingThree Gorges Medical college — Chongqing, Chongqing Municipality, China (enrolling)
• First Affiliated Hospital, Fujian Medical University, Fuzhou, China, — Fuzhou, Fujian, China (enrolling)
• Cardiovascular Hospital Xiamen University — Xiamen, Fujian, China (enrolling)
• Lanzhou University Second Hospital — Lanzhou, Gansu, China (enrolling)
• The Forth People's Hosptal of Nanhai District of Foshan City — Foshan, Guangdong, China (enrolling)
• Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) — Guangzhou, Guangdong, China (enrolling)
• Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen — Shenzhen, Guangdong, China (enrolling)
• Shenzhen Third People's Hospital，Shenzhen, Guangdong Province 518112, China — Shenzhen, Guangdong, China (enrolling)
• Shenzhen Dapeng New District Kuiyong People's Hospital — Shenzhen, Guangdong, China (enrolling)
• The First Affiliated Hospital of Guangxi Medical University — Nanning, Guangxi, China (enrolling)
• The Second Affliated Hospital Of GuangXi Medical Univesity — Nanning, Guangxi, China (enrolling)
• Nanning Third People's Hospital — Nanning, Guangxi, China (enrolling)
• Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, China. — Guiyang, Guizhou, China (enrolling)
• The Affiliated Hospital of Guizhou Medical University — Guiyang, Guizhou, China (enrolling)
• The Second Affiliated Hospital Of Guizhou Medical University — Kaili, Guizhou, China (enrolling)
• Hainan General Hospital, Department of Endocrinology — Haikou, Hainan, China (enrolling)
• The first affiliated hospital of USTC — Hefei, Anhui, China (enrolling)

Full record on ClinicalTrials.gov

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