3D Biomimetic Spine Unit Model Through the Integration of Bioprinting and Transcriptomics (CDP-SUBT)

Recruiting now

Conditions studied: Degenrative Disc Disease

In brief

The general objective of this project is to define the transcriptional profile of primary human cells derived from the nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplate (CEP), and to use this information as a reference to assess the biological relevance of a biomimetic spinal unit model obtained through bioprinting. By developing an in vitro model of human origin that incorporates key components of the spinal unit and applying transcriptional analyses to both native cells and their counterparts recovered from the 3D construct, the study will evaluate how accurately the bioprinted model reproduces the identity and heterogeneity of the native discal environment.

Key facts

Study ID

NCT07250126

Run by

I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

People needed

5

Starts

2025-11-04

Expected to finish

2027-10-01

Last updated by the study team

2025-11-26

Who can join

Age: 30 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signature of the Informed Consent for the study
• Age 30-70 years (included)
• Pfirrmann grade III-V
• Need to undergo spinal surgery

You may not qualify if…

• Presence of HIV, HBC, HCV or TPHA infection

Where it is running

• IRCCS Ospedale Galeazzi-Sant'Ambrogio — Milan, MI, Italy (enrolling)

Full record on ClinicalTrials.gov

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