Contribution of Transthoracic and Transcranial Ultrasonography to the Titration of PEEP in Patients With ARDS and ABI

Recruiting now · Not applicable

Conditions studied: Acute Respiratory Distress Syndrome (ARDS), Acute Brain Injury

In brief

The present study will investigate whether the combined use of lung and brain ultrasonography is useful in selecting the optimal positive end-expiratory pressure in mechanically ventilated critically ill patients with acute respiratory distress syndrome and acute brain injury, aiming at an individualized, brain-protective ventilation strategy.

Key facts

Study ID

NCT07248995

Run by

Theodoros Schizodimos

People needed

30

Starts

2025-12-01

Expected to finish

2027-07-01

Last updated by the study team

2025-12-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Severe acute brain injury (e.g., traumatic brain injury, subarachnoid hemorrhage, intracerebral hemorrhage, acute ischemic stroke)
• Development of ARDS (according to Berlin criteria) within the first 10 days of ICU admission

You may not qualify if…

• Severe chronic brain diseases
• Brain tumor or central nervous system (CNS) infection
• Severe chronic pulmonary or cardiovascular disease
• Severe coagulopathy
• Undergoing decompressive craniectomy
• Lack of invasive neuromonitoring
• Withdrawal of life-sustaining treatment
• Poor acoustic window in ultrasound

Where it is running

• George Papanikolaou General Hospital — Thessaloniki, Greece (enrolling)

Full record on ClinicalTrials.gov

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