Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Thermal Burns
Recruiting now
Conditions studied: Burns
In brief
This observational pilot study aims to identify criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS NEO device in pediatric burn injury. Participants will be prospectively assigned to the treatment group and compared with a retrospectively selected control group. Each patient in the treatment group will undergo two hemoadsorption sessions, each lasting 6-12 hours, with an interval of 24-120 hours between procedures. The sessions may be performed in combination with hemofiltration or hemodiafiltration at the discretion of the investigator.
Key facts
- Study ID
- NCT07248930
- Run by
- Efferon JSC
- People needed
- 30
- Starts
- 2025-10-01
- Expected to finish
- 2027-03-31
- Last updated by the study team
- 2025-11-25
Who can join
Age: 1 and older, up to 14. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Thermal burn of Ⅱ and Ⅲ severity with a lesion area of 40% or more (ICD-10: T20-T25, T29)
- Frank index >90 (Frank Index quantifies burn severity based on the depth and total surface area of the skin lesion)
- Start of hemoadsorption no later than 5 days after admission to the ICU
- The patient should receive adequate infusion therapy (at least 30 mL/kg) from the moment of inclusion in the study until the first sorption
- The patient's condition allows Efferon LPS NEO therapy to be performed for at least 6 hours
You may not qualify if…
- Presence of end-stage renal disease
- Acute pulmonary embolism, confirmed by CT scan
- Uncontrolled bleeding (acute blood loss within the last 24 hours)
Where it is running
- Children's City Clinical Hospital No. 9 named after G.N. Speransky of the Moscow City Health Department — Moscow, Russia (enrolling)
- Children's municipal multi-specialty clinical center of high medical technology — Saint Petersburg, Russia (enrolling)
Full record on ClinicalTrials.gov
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