Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Persistent Post Concussion Syndrome, Mild Traumatic Brain Injury

In brief

This project investigates an innovative combination of non-invasive neuromodulation (transcranial direct current stimulation - tDCS) and cognitive training as a novel treatment approach aimed at improving function in individuals suffering from persistent post-concussive syndrome (PPCS) following mild traumatic brain injury (mTBI).

Key facts

Study ID

NCT07246993

Run by

University of Minnesota

People needed

30

Starts

2026-03-05

Expected to finish

2028-01-01

Last updated by the study team

2026-03-17

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-65
• Has sustained a single mTBI 3-12 months prior to enrollment
• Meets criteria for PPCS (assessed using the CP Screen)
• Has reliable access to a smartphone

You may not qualify if…

• Inability to provide informed consent or complete study procedures
• History of moderate/severe TBI
• Significant neurological or psychiatric disorders (other than PPCS-related symptoms like mild depression/anxiety)
• Substance dependence within the last six months
• Contraindications to tDCS (e.g., implanted metal, skin lesions on scalp)

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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