Effect of Full-House ESS With Nasopharyngeal Lymphoid Tissue Ablation on Nasal Polyps
Recruiting now · Not applicable
Conditions studied: Nasal Polyps
In brief
This study is designed to evaluate whether the addition of nasopharyngeal lymphoid tissue ablation to full-house endoscopic sinus surgery (ESS) provides superior control of nasal mucosa inflammation compared to full-house ESS alone in patients with nasal polyps. Thirty-two adult participants will be randomly assigned to undergo either full-house ESS only or full-house ESS combined with nasopharyngeal lymphoid tissue ablation. The primary outcome will be assessed through changes in inflammatory cell profiles at 1, 3, and 6 months postoperatively. Secondary outcomes include inflammatory cytokine levels, symptom scores, endoscopic findings, polyp recurrence rates, and safety measures.
Key facts
- Study ID
- NCT07245329
- Run by
- Tongji Hospital
- People needed
- 32
- Starts
- 2025-07-01
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2025-11-24
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged 18-65 years
- Diagnosed with CRSwNP according to EPOS criteria
- Blood eosinophil count > 0.3 × 10⁹/L
You may not qualify if…
- Pregnant or lactating women.
- Cystic fibrosis
- primary ciliary dyskinesia
- fungal ball rhinosinusitis
- systemic vasculitis or granulomatous disease
- malignancy
- immunodeficiency.
- Subjects with an upper-respiratory-tract infection within the past 4 weeks.
- Clinically significant metabolic, cardiovascular, immune, neurologic, hematologic, gastrointestinal, cerebrovascular, or respiratory disorders, or any condition that, in the investigator's opinion, could interfere with outcome assessment or compromise patient safety.
- Currently participating in another clinical trial or having participated in one within 30 days, or staff directly involved in this study.
Where it is running
- Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology — Wuhan, Hubei, China (enrolling)
Full record on ClinicalTrials.gov
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