Neural Mechanisms of Light Driven Analgesia
Recruiting now · Not applicable
Conditions studied: Musculoskeletal Pain, Fibromyalgia, Healthy Controls Group - Age and Sex-matched
In brief
The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical studies. In this study the investigators will evaluate the functional connectivity between subcortical visual areas and non-image forming brain areas that are involved in pain sensation. The investigators will also evaluate how three colored light stimuli presented to the retina results in changes in whole brain evoked activation patterns in participants with chronic musculoskeletal pain and in healthy controls. The investigators will also assess while brain evoked activation patterns in response to a pressure pain stimulus in the presence of three light stimuli in individuals with chronic musculoskeletal pain and healthy controls.
Key facts
- Study ID
- NCT07245303
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 60
- Starts
- 2026-02-24
- Expected to finish
- 2030-01-31
- Last updated by the study team
- 2026-05-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Presence of retinal vision disorders or conditions resulting in vision impairment.
- Patient-reported photosensitivity, photophobia, or aversion (as may occur in autoimmune diseases such as systematic lupus erythematosus).
- Disorders including uveitis, cataracts, color-blindness, history of seizure disorder.
- Plans for analgesic treatment plan changes in next 3 months (surgery, analgesic medication changes, injections, pain procedures, etc).
- Prisoner Status.
- Pregnancy.
- Contraindications to MRI imaging. These include the presence of implanted/embedded ferromagnetic materials, implanted medical devices that are not MRI compatible, and claustrophobia.
Where it is running
- University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States (enrolling)
Full record on ClinicalTrials.gov
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