Fetal Fornix and Hippocampus in Pregnant Women With Early-Onset Preeclampsia
Recruiting now · Not applicable
Conditions studied: Pre-Eclampsia, Hippocampus
In brief
Since early-onset preeclampsia (EOPE) is commonly associated with inadequate placentation, placental insufficiency, chronic fetal hypoxia, oxidative stress, and heightened inflammation, these pathological processes may adversely affect hippocampal neuronal development and maturation of axonal pathways such as the fornix. These mechanisms support our hypothesis that fetal fornix and hippocampus dimensions may be reduced in pregnancies complicated by EOPE, forming the scientific basis of our study. Previous research has suggested a potential link between preeclampsia (PE) and altered neurocognitive development. However, no studies to date have specifically evaluated the relationship between EOPE and fetal fornix or hippocampus dimensions. Therefore, the objective of our study is to assess fetal fornix and hippocampus measurements in pregnant women with early-onset preeclampsia compared with healthy controls.
Key facts
- Study ID
- NCT07245056
- Run by
- Ankara Etlik City Hospital
- People needed
- 84
- Starts
- 2025-12-01
- Expected to finish
- 2026-08-01
- Last updated by the study team
- 2025-12-23
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Women aged 18-45 years
- Gestational age between 20 and 34 weeks
- Diagnosis of early-onset preeclampsia (EOPE)
- Singleton pregnancy
You may not qualify if…
- Multiple pregnancies
- Presence of chronic or significant comorbid conditions other than maternal early-onset preeclampsia, including: Chronic, mental, or physical illnesses, severe renal, hepatic, or gastrointestinal acute or chronic inflammatory diseases, hyperthyroidism or hypothyroidism, chronic hypertension, type 1 or type 2 diabetes mellitus, history of polycystic ovary syndrome (PCOS), history of malignancy
- Fetal congenital or chromosomal anomalies
- Chronic medication use
- Tobacco or alcohol use during pregnancy
- Maternal late-onset preeclampsia (≥34 weeks gestation)
Where it is running
- Ankara Etlik City Hospital — Ankara, Yenimahalle, Turkey (Türkiye) (enrolling)
Full record on ClinicalTrials.gov
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