MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

Recruiting now · Not applicable

Conditions studied: Femoral Neck Fractures

In brief

This study is an intervention domain of the Musculoskeletal Adaptive Platform Trial. The primary goal of this pragmatic, randomized, open-label, comparative effectiveness trial is to evaluate if arthroplasty is superior to internal fixation when used to treat minimally displaced femoral neck fractures in older adults ≥60 years old. We hypothesize that arthroplasty will reduce death, preserve ambulation, increase days alive and out of hospital, and improve health status compared to internal fixation within 4 months and 12 months from randomization.

Key facts

Study ID

NCT07244211

Run by

University of Southern California

People needed

600

Starts

2026-01-23

Expected to finish

2030-01-31

Last updated by the study team

2026-07-30

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 60 years of age or older undergoing surgery due to a minimally displaced femoral neck fracture
• The patient has a health condition affecting physical mobility.
• Complete fracture of the femoral neck (AO/OTA 31B) confirmed with anteroposterior and lateral hip radiographs, computed tomography, or magnetic resonance imaging.
• Minimally displaced fracture that could be, in the judgment of the attending surgeon, managed with either arthroplasty or in situ internal fixation without reduction.
• Low energy injury mechanism.
• Surgeons with expertise in internal fixation and total hip arthroplasty or hemiarthroplasty are available to perform surgery.

You may not qualify if…

• The patient is not clinically suitable for either compared treatment.
• Expected injury survival of less than 12 months.
• Terminal illness with expected survival of less than 12 months.
• Incarceration.
• Unable to obtain informed consent due to language barriers.
• Unable to obtain informed consent because the legally authorized representative was unavailable.
• Problems, in the judgment of the study personnel, with maintaining follow-up with the patient.
• Currently enrolled in a study or intervention domain that does not permit co-enrollment.
• Prior enrollment in the specific platform trial intervention domain.
• Patient or legally authorized representative did not provide informed consent (declined participation).
• Eligible patient or legally authorized representative was not approached within the screening window (missed participant).
• Other reasons to exclude the patient, as approved by the data coordinating center.
• Associated lower extremity injury that prevents post-operative weight-bearing.
• Retained hardware around the hip that precludes either study treatment.
• Infection around the hip (soft tissue or bone).
• Pathologic fracture with a lytic lesion in the femoral neck that precludes internal fixation.
• Injury did not occur within 21 days of screening.
• Patient is too ill, in the judgment of the attending surgeon, for internal fixation.
• Patient is too ill, in the judgment of the attending surgeon, for arthroplasty.

Where it is running

• University of California, Irvine — Irvine, California, United States (enrolling)
• Los Angeles General Medical Center — Los Angeles, California, United States (enrolling)
• University of Southern California — Los Angeles, California, United States (enrolling)
• Cedars-Sinai Medical Center — Los Angeles, California, United States (enrolling)
• University of Wisconsin - Madison — Madison, Wisconsin, United States (enrolling)
• University of British Columbia — Vancouver, British Columbia, Canada (enrolling)
• Fraser Health Authority — Vancouver, British Columbia, Canada (enrolling)
• London Health Sciences Centre — London, ON, United Kingdom (enrolling)
• Indiana University — Bloomington, Indiana, United States (enrolling)
• University of Maryland, Baltimore - R Adams Cowley Shock Trauma Center — Baltimore, Maryland, United States (enrolling)
• University of Maryland Capital Region Health — Largo, Maryland, United States (enrolling)
• University of Mississippi — University, Mississippi, United States (enrolling)
• University of Cincinnati — Cincinnati, Ohio, United States (enrolling)
• University of Oklahoma Health Sciences Center — Oklahoma City, Oklahoma, United States (enrolling)
• Prisma Health-Upstate — Greenville, South Carolina, United States (enrolling)
• Vanderbilt University — Nashville, Tennessee, United States (enrolling)
• University of Utah — Salt Lake City, Utah, United States (enrolling)
• Inova Health Care Services — Fairfax, Virginia, United States (enrolling)
• University of Miami — Miami, Florida, United States
• St. Luke's University Health System — Allentown, Pennsylvania, United States
• Hospital Universitari Vall d'Hebron — Barcelona, Spain
• University of Vermont — Burlington, Vermont, United States

Full record on ClinicalTrials.gov

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