A Prospective Real-World Observational Study of Nanocrystalline Megestrol Acetate in Patients With Cancer Cachexia
Recruiting now · Phase 4
Conditions studied: Clinical Characteristics and Treatment Outcomes of Malignant Tumor Cachexia, Multicenter Observational Study
In brief
This study is a prospective, real-world observational study. The objective is to evaluate the effectiveness and safety of nanocrystalline megestrol acetate in patients with cancer cachexia in real-world settings. Eligible participants were patients diagnosed with cancer cachexia who were scheduled to receive treatment with nanocrystalline megestrol acetate.
Key facts
- Study ID
- NCT07243379
- Run by
- Changchun GeneScience Pharmaceutical Co., Ltd.
- People needed
- 495
- Starts
- 2025-09-25
- Expected to finish
- 2027-06-30
- Last updated by the study team
- 2025-11-21
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with histologically and/or cytologically confirmed malignancy.
- Age ≥18 years at enrollment.
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2 and an expected survival of ≥3 months.
- Meeting the diagnostic criteria for cachexia (based on Fearon's criteria).
- Body mass index (BMI) ≤30.
You may not qualify if…
- Presence of any condition affecting gastrointestinal absorption, such as dysphagia, malabsorption, or uncontrolled vomiting; patients receiving tube feeding or parenteral nutrition.
- Presence of anorexia due to anorexia nervosa, psychiatric disorders, or pain that makes eating difficult.
- Patients with acquired immunodeficiency syndrome (AIDS).
- Currently receiving or planning to receive other medications that increase appetite or body weight, such as corticosteroids (except short-term dexamethasone during chemotherapy), androgens, progestins, thalidomide, olanzapine, anamorelin, or other appetite stimulants.
- Patients with Cushing's syndrome, adrenal or pituitary insufficiency, or poorly controlled diabetes mellitus.
Where it is running
- Henan Cancer Hospital, Affiliated to Zhengzhou University — Zhengzhou, Henan, China (enrolling)
Full record on ClinicalTrials.gov
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