SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease

Completed · Phase 4

Conditions studied: Dry Eye Disease (DED)

In brief

This is a prospective, randomized, double-masked, multi-site clinical trial designed to compare the efficacy of SYSTANE® PRO (Alcon Laboratories, Inc.) to MIEBO™ (Bausch + Lomb) in treating symptoms of evaporative dry eye disease (DED). The primary goal is to determine whether SYSTANE® PRO is non-inferior to MIEBO™ after one month of treatment, based on change in Ocular Surface Disease Index (OSDI) scores.

Key facts

Study ID

NCT07243275

Run by

Indiana University

People needed

269

Starts

2026-02-18

Expected to finish

2026-07-28

Last updated by the study team

2026-08-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults>=18 years of age
• Corrected visual acuity of 20/100 or better in both eyes
• Ocular Surface Disease Index [OSDI] scores between 23 and 50 units [inclusive]
• Tear break up time score of <=5 seconds in both eyes
• Schirmer I test (without anesthesia) >=5 mm in both eyes

You may not qualify if…

• Discontinue contact lens wear starting 7 days prior and throughout the study
• Artificial tears and warm compresses should not be used for at least one week prior to enrollment and throughout the study
• Systemic health conditions that are known to alter tear film physiology(e.g., primary and secondary Sjogren's syndrome)
• History of ocular surgery within the past 12 months
• History of severe ocular trauma, active ocular infection or inflammation, have ever used Accutane or are currently using ocular medications.
• Women who are pregnant or breast feeding(self report)
• Subjects with a condition or in a situation, which in the investigator's opinion, may put the subject at significant rist, may confound the study results, or may significantly interfere with their participation in the study
• Subjects will not be allowed to use any other topical eye drops or other dry eye treatments beyond their assignment during the study
• Participants in clinical trial or study using a device, topical, or oral therapeutic in the past 3 months of enrollment

Where it is running

• Eye Research Foundation — Newport Beach, California, United States
• Indiana Universtiy School of Optometry — Bloomington, Indiana, United States
• Kannarr Eye Care — Pittsburg, Kansas, United States
• Southern College of Optometry — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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