A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006)
Recruiting now · Phase 1 · Has a placebo group
Conditions studied: Diabetes Mellitus, Type 2
In brief
The purpose of this study is to learn about the safety and if people tolerate a study medicine called MK-1403. The study will also measure what happens to MK-1403 in the body of a person with type 2 diabetes (T2D) over time (pharmacokinetic or PK study), and how it affects the amount of high-sensitivity C-reactive protein (hsCRP) in a person's blood.
Key facts
- Study ID
- NCT07242469
- Run by
- Merck Sharp & Dohme LLC
- People needed
- 52
- Starts
- 2025-12-22
- Expected to finish
- 2026-09-03
- Last updated by the study team
- 2026-07-31
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Has a confirmed diagnosis of Type 2 diabetes mellitus (T2DM)
- Has body mass index (BMI) between 18 and 40 kg/m\^2, inclusive
You may not qualify if…
- Has Type 1 diabetes mellitus or secondary types of diabetes
- Has a history of congestive heart failure (New York Heart Association [NYHA] Class 3 or 4)
- Has history of myocardial infarction, uncontrolled arrhythmias, cardiac revascularization, angina, unstable peripheral arterial disease and/or stroke
- Has history of cancer (malignancy)
- Has positive test(s) for hepatitis B surface antigen (HBsAg), hepatitis C antibodies, or human immunodeficiency virus (HIV)
- Has a history of gastrointestinal (GI) disease which might affect food and drug absorption, or has had gastric bypass or similar surgery
Where it is running
- Anaheim Clinical Trials ( Site 0006) — Anaheim, California, United States (enrolling)
- ProSciento Inc. ( Site 0001) — Chula Vista, California, United States (enrolling)
- Advanced Pharma CR, LLC ( Site 0003) — Miami, Florida, United States (enrolling)
- QPS-MRA, LLC ( Site 0004) — South Miami, Florida, United States (enrolling)
- Bio-Kinetic Clinical Applications, LLC dba QPS-MO ( Site 0005) — Springfield, Missouri, United States
Full record on ClinicalTrials.gov
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