Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation
Recruiting now · Not applicable
Conditions studied: Alveolar Ridge Preservation, Post Extraction Alveolar Bone Resorption
In brief
This clinical investigation aims to assess how two different allogeneic dentin graft materials - one de-mineralized and the other mineralized - influence bone preservation following extraction of a single upper posterior tooth. A total of 45 patients will be randomly allocated into three equal groups: a socket-only spontaneous healing group (control), a de-mineralized dentin graft group, and a mineralized dentin graft group. Over a six-month period after extraction, measurements will be taken using CBCT to monitor changes in ridge width, height, and bone density. Secondary outcomes include patient-reported pain, postoperative swelling, satisfaction levels, width of keratinized tissue, and histomorphometric data from biopsy samples at implant placement. Findings from this trial may support evidence-based decisions in alveolar ridge preservation and help clinicians choose the most predictable grafting strategy before implant placement.
Key facts
- Study ID
- NCT07242313
- Run by
- Kafrelsheikh University
- People needed
- 45
- Starts
- 2025-10-21
- Expected to finish
- 2026-08-31
- Last updated by the study team
- 2025-11-24
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 18 to 60 years.
- Medically healthy patients classified as ASA I.
- Presence of a single non-restorable tooth indicated for extraction in the posterior maxilla.
- Adequate oral hygiene, with plaque and bleeding indices both below 20%.
- Sufficient bone volume to allow socket preservation without requiring simultaneous augmentation.
- Patients willing to participate in the study and able to provide written informed consent.
- Ability to commit to follow-up visits for up to 6 months.
You may not qualify if…
- Smokers or tobacco users of any form.
- Presence of uncontrolled systemic diseases (e.g., uncontrolled diabetes).
- Conditions affecting bone metabolism (e.g., osteoporosis, long-term corticosteroid therapy).
- Pregnant or lactating women.
- History of radiotherapy in the head and neck region.
- Active infection or suppuration at the extraction site.
- Immunocompromised patients or those on immunosuppressive therapy.
- Patients taking medications known to impair healing (e.g., bisphosphonates).
- Allergy or hypersensitivity to any study-related materials.
Where it is running
- Faculty of Dentistry, Kafrelsheikh University — Kafr ash Shaykh, Egypt (enrolling)
Full record on ClinicalTrials.gov
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