A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AG-181 in Subjects With Phenylketonuria

Recruiting now · Phase 1

Conditions studied: Phenylketonuria

In brief

The primary purpose of this study is to assess the safety and tolerability of AG-181 in subjects with Phenylketonuria (PKU).

Key facts

Study ID

NCT07241234

Run by

Agios Pharmaceuticals, Inc.

People needed

20

Starts

2026-04-17

Expected to finish

2028-01-17

Last updated by the study team

2026-07-30

Who can join

Age: 18 and older, up to 69. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Indiana University — Indianapolis, Indiana, United States (enrolling)
• UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States (enrolling)
• University of Texas Southwestern Medical Center (UTSW) — Dallas, Texas, United States (enrolling)
• Centrum Wsparcia Badań Klinicznych Pomorskiego Uniwersytetu Medycznego w Szczecinie — Szczecin, West Pomeranian Voivodeship, Poland (enrolling)

Full record on ClinicalTrials.gov

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