Aspirin Continuation or Discontinuation in Conservative Treatment for Chronic Subdural Hematoma

Recruiting now · Not applicable

Conditions studied: Chronic Subdural Hematoma

In brief

This clinical study aims to learn about the efficacy and safety of aspirin continuation or discontinuation in conservative treatment for chronic subdural hematoma. All participants received standard conservative treatment for chronic subdural hematoma, with a randomized intervention to either continue or discontinue aspirin administration. By participating in this study, participants can receive additional scientific guidance on aspirin medication management beyond routine conservative treatment, thereby optimizing individualized therapy.

Key facts

Study ID

NCT07240454

Run by

Tao Liu

People needed

143

Starts

2025-10-15

Expected to finish

2028-12-01

Last updated by the study team

2025-11-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years, male or female;
• Confirmed diagnosis of chronic subdural hematoma (cSDH) by cranial CT and/or MRI;
• Intended for conservative management (i.e., no surgical evacuation indication at enrollment);
• Regular aspirin use at enrollment;
• Informed consent signed by the patient or legal representative.

You may not qualify if…

• Patients requiring emergency surgery to remove hematoma at enrollment;
• Concurrent use of other anticoagulants or antiplatelet agents that cannot be discontinued according to the study protocol;
• cSDH secondary to other diseases or conditions (e.g., excessive drainage from ventriculoperitoneal shunts, intracranial tumors);
• Active bleeding events or major cardiac events (e.g., acute myocardial infarction, unstable angina, or revascularization surgery) within 30 days prior to enrollment;
• Known bleeding disorders (e.g., hemophilia, severe thrombocytopenia);
• Individuals unable to provide informed consent or for whom completion of follow-up is anticipated to be difficult.

Where it is running

• Xuanwu Hospital Capital Medical University — Beijing, China (enrolling)
• Tianjin Medical University General Hospital — Tianjin, China (enrolling)

Full record on ClinicalTrials.gov

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