Evaluating Atherosclerotic Disease Progression in Patients With Diabetes Mellitus
Recruiting now
Conditions studied: Type 2 Diabetes, Coronary Artery Disease (CAD), Atherosclerosis Cardiovascular Disease
In brief
People with type 2 diabetes have a much higher risk of heart disease. One common problem is when the blood vessels that supply the heart become narrowed or blocked by fatty deposits, called plaque. This makes it harder for blood to reach the heart and can lead to serious problems such as chest pain, heart attacks, or even death. This study will follow people with type 2 diabetes who have already had a special heart scan called a coronary CT angiography. This scan takes detailed pictures of the heart's blood vessels. The goal is to understand how heart disease changes over time in people with type 2 diabetes, by looking at repeat scans and other health information. By learning more about how plaque builds up or gets worse, researchers hope to find better ways to identify which patients are most at risk for future heart problems.
Key facts
- Study ID
- NCT07237685
- Run by
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- People needed
- 1000
- Starts
- 2025-06-06
- Expected to finish
- 2036-10-01
- Last updated by the study team
- 2025-11-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age over 18 years
- Previous completion of CCTA scan for CAD assessment
- Diagnosed with Type 2 Diabetes and currently receiving glucose lowering treatment
- Sufficient image quality of the CCTA scan (at least 2/3 vessels of sufficient quality for assessment).
You may not qualify if…
- Inability to provide written informed consent
- Presence of an unstable condition
- Ingeligibility for CCTA acquisition due to severe renal dysfunction (eGFR ≤ 30 mL/min/1.73m²) or known hypersensitivity or contraindication to CT contrast agents
- Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
- inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study
- Baseline (routine care) CCTA performed < 2 years or > 5 years before inclusion
Where it is running
- Cardiology Centers of the Netherlands — Amsterdam, Netherlands (enrolling)
- Amsterdam University Medical Centers — Amsterdam, Netherlands
Full record on ClinicalTrials.gov
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