Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation

Recruiting now

Conditions studied: Infant, Preterm, Respiratory Distress Syndrome (Neonatal), Chronic Lung Disease of Newborn, Respiratory Support, Synchronized Noninvasive Positive Pressure Ventilation (SNIPPV), Lung Volume

In brief

Current evidence suggests that noninvasive positive pressure ventilation (NIPPV) is more effective than continuous positive airway pressure (CPAP) in preventing respiratory failure in preterm infants with respiratory distress syndrome (RDS), both as initial and post-extubation support. NIPPV may be delivered in synchronized (sNIPPV) or non-synchronized (nsNIPPV) modes, with sNIPPV offering clear benefits by coordinating support with the infant's own breathing. Recent studies indicate sNIPPV is superior to nsNIPPV in preventing respiratory failure, though the intrapulmonary mechanisms behind this advantage remain unclear. To address this, the present study uses Electrical Impedance Tomography (EIT) to evaluate how lung volume changes during different types of breaths and ventilator inflations - spontaneous breaths, synchronized inflations, non-synchronized inflations, and backup inflations - in preterm infants receiving sNIPPV.

Key facts

Study ID

NCT07237139

Run by

University of Zurich

People needed

27

Starts

2025-11-17

Expected to finish

2027-01-30

Last updated by the study team

2025-12-09

Who can join

Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Written informed consent by one or both parents or legal guardians
• Gestational age at birth < 30 0/7 weeks
• Infants on sNIPPV respiratory support
• Below 4 weeks chronological age

You may not qualify if…

• Severe congenital malformation adversely affecting lung aeration or perfusion (e.g., congenital heart defects)
• Too ill/unstable in the opinion of the treating physician.

Where it is running

• University Hospital Zurich — Zurich, Canton of Zurich, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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