Self-administered Remote Neurological Examination Using Mobile Application in Patients With Brain Tumors

Recruiting now

Conditions studied: CNS Tumor, Artificial Intelligence (AI), Glioma, Digital Health

In brief

The goal of this observational study is to evaluate the feasibility and accuracy of a self-administered remote neurological examination using the "Iskhaa" mobile application in patients with brain tumors aged above 5 years who are able to follow app-based instructions. The main questions it aims to answer are: 1. Development of a mobile application equipped with symptom assessment and recording videos as patients perform specific neurological tasks. 2. Development and validation of the AI model to detect functional changes and predict subsequent neurological deterioration. Participants will: 1. Use the Iskhaa mobile application to perform guided self-neurological examinations following pre-recorded video instructions. 2. Complete EORTC QLQ-C30 and BN20 questionnaires for quality of life assessment. 3. Record and upload videos (e.g., speech, walking, limb movements) using their mobile camera for analysis. 4. In Phase 1 (onsite), 100 participants will use the app under supervision to ensure usability and accuracy. 5. In Phase 2 (offsite), 500 participants will use the app independently at home for monthly self-assessments, with reminders and follow-up support. 6. Continue routine clinic visits every 3-6 months and imaging every 6-12 months as per standard clinical care. The study will compare app-recorded data with physician assessments to determine agreement and validity of remote neurological monitoring using artificial intelligence analysis.

Key facts

Study ID

NCT07236840

Run by

Tata Memorial Centre

People needed

600

Starts

2026-02-20

Expected to finish

2027-11-05

Last updated by the study team

2026-02-24

Who can join

Age: 5 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of brain tumors (histopathology/ radiology).
• Age > 5 years
• Patient or caregiver have access to an android smart phone and is able to install the mobile application.
• Expected survival more than 6 months during study accrual.
• Signing patient consent or parent consent/ child assent form (as appropriate).

You may not qualify if…

• Patient or caregiver is not reliable to follow instructions or use the mobile application.
• Patient with severe cognitive or psychiatric issues causing difficulty in using the app or follow instructions.
• Karnofsky Performance Status (KPS) or Lansky Performance Status LPS) <50.
• Terminal illness with expected life expectancy (<6 months).

Where it is running

• Tata Memorial Centre — Mumbai, Maharashtra, India (enrolling)

Full record on ClinicalTrials.gov

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