Effects of tES Combined With CMDT Gait Training on Cognition, Cortical Activity, Spinal Motoneuron Excitability and Motor Performance in Stroke Individuals

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Hemorrhagic Stroke, Ischemic Stroke, Subacute Stroke, Chronic Stroke Patient

In brief

The present study will use transcranial electrical stimulation (tES) which are transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) combined with conventional physical therapy and cognitive-motor dual task gait training in sub-acute (at least 2 weeks after stroke onset) to chronic (within 5 years post-stroke) to investigate the effect on cortical activity, spinal motoneuron excitability, cognition and motor performance. The findings may enhance the evidence to support usages of tES for improvimg cognition, motor performance as well as cortical activity and spinal motoneuron excitability in a clinical setting.

Key facts

Study ID

NCT07236216

Run by

Mahidol University

People needed

60

Starts

2025-12-20

Expected to finish

2027-12-30

Last updated by the study team

2026-02-23

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Unilateral stroke individuals aged 18-80 years.
• A first-ever stroke.
• Stroke onset from at least 2 weeks-5 years.
• Able to walk independently with or without gait aids (modified Rankin scale (mRS) 1-3)
• Montreal cognitive Assessment-Thai version (MoCA-T) greater than or equal to 20 scores.
• Ability to read, communicate, follow and understand instructions.

You may not qualify if…

• Presence of any psychological or neurological antecedent, unstable medical conditions or condition that may increase risk of stimulation such as epilepsy, seizure, and history of brain injury
• Having unstable cardiovascular disease or respiratory disease, and uncontrolled chronic disease such as diabetes mellitus (DM), hypertension (HT) and chronic kidney disease (CKD)
• Receiving other non-invasive brain stimulation or additional intervention such as TMS, PMS or acupuncture
• Presence of metal implantation, intracranial shunt, cochlear implantation, or cardiac pacemakers.
• Presence of an opened wound, infectious wound around scalp or craniectomy with unreplaced bone flap
• Moderate pain (numeric pain rating score > 4/10) in any joint of the upper or lower limb, whether paretic or non-paretic
• Presence of color blindness
• Presence of any substance use including cannabis and kratom

Where it is running

• Faculty of Physical Therapy, Mahidol University — Nakhon Pathom, Thailand (enrolling)

Full record on ClinicalTrials.gov

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