Non-Invasive Diagnosis and Monitoring of Cardiac Masses by Liquid Biopsy

Recruiting now

Conditions studied: Cardiac Masses

In brief

This is a nonprofit, observational, prospective and retrospective,multicenter study in a population of young and adult patients ≥12 years with a diagnosis of a cardiac mass. The study will include both patients with masses of unknown pathological diagnosis and patients with a known histology of benign or malignant tumors. We predict a case-control allocation ratio of 1:1 between cardiac malignant tumors and benign lesions. Peripheral blood will be collected at participating centers during routine venipuncture,processed and then shipped for liquid biopsy ctDNA NGS analyses. If available, in malignant cases, matched tumor tissue samples collected as per clinical practice solid biopsies or surgery will be used for analyses. Longitudinal tracking through serial blood draws could be performed in selected cases of patients with cardiac malignancies who receive cancer treatment

Key facts

Study ID

NCT07235865

Run by

Niguarda Hospital

People needed

26

Starts

2024-07-25

Expected to finish

2026-12-25

Last updated by the study team

2026-04-15

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥12 years old
• Suspected or confirmed diagnosis of a cardiac mass of any nature as assessed by standard clinical, radiological and/or pathological procedures.

You may not qualify if…

• Inability of the pa ent to fully understand and sign the informed consent.

Where it is running

• Niguarda Hospital — Milan, Italia, Italy (enrolling)

Full record on ClinicalTrials.gov

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