Kinetic Analysis of Immune Cells in Blood and Chronic Graft-Versus-Host Disease-Affected Tissues After Allogeneic Hematopoietic Cell Transplantation
Recruiting now
Conditions studied: Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
In brief
This study evaluates the factors that contribute to chronic graft-versus-host disease, which is a complication that can occur after allogeneic hematopoietic cell transplantation.
Key facts
- Study ID
- NCT07235501
- Run by
- City of Hope Medical Center
- People needed
- 75
- Starts
- 2026-10-01
- Expected to finish
- 2030-01-17
- Last updated by the study team
- 2026-07-22
Who can join
Age: 7 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- * BOTH COHORTS:
- Documented written informed consent of the participant and/or parent/guardian.
- Assent from pediatric participants will be documented per institutional policies and practice.
- Patients who have received allogeneic hematopoietic cell transplant (HCT) regardless of donor type, condition regimen, or GVHD prophylaxis.
- Age: ≥ 18 years or ≥ 7 years if 30 kg and above
- Willingness to:
- Provide blood sample(s), stool, saliva, and buccal mucosa,
- If applicable: Permit medical record/ clinical laboratory result review
- COHORT 1:
- Patients who have received allogeneic hematopoietic cell transplant (HCT) regardless of donor type, condition regimen, or GVHD prophylaxis.
- COHORT 2:
- Patients diagnosed with cGVHD at any time-point after allogeneic HCT regardless of donor type, condition regimen, or GVHD prophylaxis.
You may not qualify if…
- * Women of childbearing potential: Pregnant/nursing
- Individuals with impaired decision-making capacity
- An employee who is under the direct/ indirect supervision of the PI/ a co-investigator/ the study manager
- A direct study team member
Where it is running
- City of Hope Medical Center — Duarte, California, United States (enrolling)
Full record on ClinicalTrials.gov
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