A Study of DII235 in Adults With Elevated Lipoprotein(a)

Running, not enrolling · Phase 2

Conditions studied: Lipoprotein Disorder

In brief

The main purpose of this study is to determine the safety and efficacy of DII235 in adults with elevated lipoprotein(a).

Key facts

Study ID

NCT07235046

Run by

Novartis Pharmaceuticals

People needed

234

Starts

2025-12-02

Expected to finish

2028-04-25

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed informed consent must be obtained prior to participation in the study.
• Male or female participants 18 to 80 years of age (inclusive) at the screening.
• Lp(a) ≥ 150 nmol/L at screening, measured at the central laboratory.
• Participants with evidence of atherosclerotic cardiovascular disease and/or type 2 diabetes mellitus.

You may not qualify if…

• Severe renal dysfunction
• Hepatic dysfunction
• Malignancy within the last 5 years
• Use of investigational medications as defined in the protocol
• History or presence at screening of an underlying disease, or surgical, physical, medical, or psychiatric condition that, in the opinion of the Investigator, or sponsor if consulted, would potentially affect participant safety within the study or interfere with participating in or completing the study or with the interpretation of data
• Other protocol-defined inclusion/exclusion criteria may apply

Where it is running

• Heart Center Research Llc — Huntsville, Alabama, United States
• Cardiology and Medicine Clinic PA — Little Rock, Arkansas, United States
• National Heart Institute — Beverly Hills, California, United States
• Alliance Clinical — Canoga Park, California, United States
• Excel Medical Clinical Trials LLC — Boca Raton, Florida, United States
• Zenith Clinical Research — Hollywood, Florida, United States
• Jacksonville Center for Clinical Research — Jacksonville, Florida, United States
• Flourish Res Acq LLC North Miami — Miami, Florida, United States
• Inpatient Research Clinical LLC — Miami Lakes, Florida, United States
• Ocala Cardiovascular Research — Ocala, Florida, United States
• SEC Clinical Research — Pensacola, Florida, United States
• Cardiology Partners Clinical Research Institute — Wellington, Florida, United States
• Atlanta Heart Specialists LLC — Tucker, Georgia, United States
• AMR Chicago — Niles, Illinois, United States
• CV Ins of the South — Lafayette, Louisiana, United States
• Monroe Research Llc — West Monroe, Louisiana, United States
• Metropolitan Cardiovascular Consultants Llc — Beltsville, Maryland, United States
• Anderson Medical Research — Ft. Washington, Maryland, United States
• Capitol Cardiology Associates — Lanham, Maryland, United States
• AA Medical Research Center — Flint, Michigan, United States
• Trinity Health Michigan Heart — Ypsilanti, Michigan, United States
• Cardiology Associates of North MS — Tupelo, Mississippi, United States
• AB Clinical Trials — Las Vegas, Nevada, United States
• K and R Research LLC — Marion, Ohio, United States
• Parkway Medical Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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