Complications of the Alveolar Opening Maneuver in Children on Mechanical Ventilation

Recruiting now

Conditions studied: Positive End-expiratory Pressure (PEEP), Oxygenation Index, Pediatric Intensive Care Unit, Pediatric Acute Lung Injury, Respiratory Distress Syndrome, Pediatric, Complication

In brief

The objective of this research is to analyze the overall incidence of complications associated with a therapeutic maneuver known as alveolar opening and subsequent titration of positive end-expiratory pressure (PEEP) in pediatric patients with acute respiratory distress syndrome (ARDS). These procedures are part of the standard care provided in the Pediatric Intensive Care Unit (PICU) and are used to improve pulmonary oxygenation and respiratory mechanics. Through this study, we aim to gather information that will help improve the safety and effectiveness of these interventions in critically ill patients.

Key facts

Study ID

NCT07233304

Run by

Hospital de Alta Complejidad en Red

People needed

143

Starts

2025-08-18

Expected to finish

2026-08-01

Last updated by the study team

2025-11-18

Who can join

Age: 0 and older, up to 14. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients under 14 years of age admitted to the HCANK PICU
• More than 4 hours of invasive mechanical ventilation (IMV)
• An oxygenation index (OI) ≥4 or an oxygen saturation index (OSI) ≥5
• Indication for ARM and PEEP as determined by the treating team

You may not qualify if…

• Predicted body weight (PBW) >45.5 kg
• Recent pulmonary resection surgery (<7 days)
• Presence of broncho-pleural fistula or peri-tube leak >25% of the tidal volume
• Hemoglobin decline <7 g/dL
• Patients with congenital or acquired heart diseases with significant intracardiac shunt.

Where it is running

• Hospital Cuenca Alta Néstor Kirchner — Canuelas, Buenos Aires, Argentina (enrolling)

Full record on ClinicalTrials.gov

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