A Study to Evaluate How the Study Drug Moves Through the Body, Adverse Events, and How the Body Tolerates ABBV-547 Injections

Running, not enrolling · Phase 1 · Has a placebo group

Conditions studied: Healthy Volunteer

In brief

The purpose of this study is to assess how safe, effective, and tolerable ABBV-547 is in adult participants in the United States and Japan. There will be 2 parts to this study. In Part 1, participants are placed in one of 7 groups where they will receive ABBV-547 at different doses or placebo. There is a 1 in 4 chance participants will receive placebo. In Part 2, participants are placed in one of 3 groups where they will receive ABBV-547 at different doses or placebo. There is a 1 in 7 chance participants will receive placebo. Approximately 121 adult participants will be enrolled at approximately 21 sites in the United States and Japan. Participants will be administered one dose of ABBV-547 or placebo. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.

Key facts

Study ID

NCT07232004

Run by

AbbVie

People needed

121

Starts

2025-11-24

Expected to finish

2027-08-01

Last updated by the study team

2026-07-24

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile and a 12-lead electrocardiogram (ECG).
• Part 1: BMI is >= 18.0 to <= 29.9 kg/m\^2 after rounding to the tenths decimal at Screening. BMI is calculated as weight in kg divided by the square of height measured in meters.
• Part 2: must have discontinued use of phototherapy (e.g., UVA or UVB) at least 2 weeks prior to the baseline visit (Day 1) and PUVA phototherapy at least 4 weeks prior to the baseline visit (Day 1).

You may not qualify if…

• History of any clinically significant sensitivity or allergy to any medication or food.
• Part 2: uses any herbal supplements within the 2-week period prior to study treatment administration.
• Part 2: received any biologics including investigational agents within 2.5 half-lives prior to Baseline.

Where it is running

• Total Dermatology /ID# 279798 — Birmingham, Alabama, United States
• Dermatology Trial Associates /ID# 279984 — Bryant, Arkansas, United States
• CenExel ACT- Anaheim Clinical Trials /ID# 279612 — Anaheim, California, United States
• Dermatology Research Associates - Los Angeles /ID# 279383 — Los Angeles, California, United States
• Integrative Skin Science and Research - Location 2 /ID# 279386 — Sacramento, California, United States
• Skin Care Research Boca Raton /ID# 279988 — Boca Raton, Florida, United States
• Wellness Clinical Research - Miami Lakes /ID# 279803 — Miami Lakes, Florida, United States
• Advanced Clinical Research Institute - Tampa /ID# 279342 — Tampa, Florida, United States
• Trueblue Clinical Research - Tampa /ID# 281757 — Tampa, Florida, United States
• University Dermatology & Vein Clinic - Darien /ID# 279986 — Darien, Illinois, United States
• Acpru /Id# 278638 — Grayslake, Illinois, United States
• MetroBoston Clinical Partners /ID# 279992 — Boston, Massachusetts, United States
• Minnesota Clinical Study Center /ID# 279987 — New Brighton, Minnesota, United States
• MediSearch Clinical Trials /ID# 279416 — Saint Joseph, Missouri, United States
• Skin Specialists /ID# 279531 — Omaha, Nebraska, United States
• The Skin Center Dermatology Group /ID# 279983 — New City, New York, United States
• Equity Medical, LLC - Bronx /ID# 279808 — The Bronx, New York, United States
• Oregon Dermatology and Research Center /ID# 279391 — Portland, Oregon, United States
• Health Concepts /ID# 279529 — Rapid City, South Dakota, United States
• Center for Clinical Studies - Houston - Binz Street /ID# 279419 — Houston, Texas, United States
• Austin Institute for Clinical Research - Pflugerville /ID# 279387 — Pflugerville, Texas, United States
• University of the Ryukyus Hospital /ID# 279918 — Ginowan-shi, Okinawa, Japan
• Fukuoka University Hospital /ID# 279530 — Fukuoka, Japan

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.