AD-SVF Therapy for Refractory Endometrial Infertility
Recruiting now · Phase 1
Conditions studied: Endometrium; Atrophy, Intrauterine Synechiae
In brief
The purpose of this study is to initially explore the efficacy of adipose-derived stromal vascular fraction (AD-SVF) therapy in the treatment of refractory endometrial infertility.
Key facts
- Study ID
- NCT07230600
- Run by
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
- People needed
- 10
- Starts
- 2025-11-01
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2025-11-18
Who can join
Age: 22 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- refractory thin endometrium (endometrial thickness < 6 mm on the day of ovulation or the day of endometrial transformation during a hormone replacement cycle) and/or moderate to severe intrauterine adhesion；
- Inability to undergo autologous bone marrow stem cells-scaffold (BMSC) transplantation due to failed bone marrow aspiration, or lack of significant effect following the BMSC treatment;
- with fertility intentions;
- normal ovarian function or availability of cryopreserved embryos;
- 18kg/m\^2 < body mass index (BMI) < 30kg/m\^2;
You may not qualify if…
- Chromosomal karyotype abnormalities in one spouse;
- Severe endometriosis, uterine fibroids affecting the uterine cavity morphology, or uterine malformations;
- Abnormalities in coagulation function, hepatic or renal function, or other underlying conditions deemed by the investigator to potentially impact the study's progression (uncontrolled hypertension, diabetes, autoimmune diseases, etc.);
- Contraindications for pregnancy;
- Contraindications for hormonal cycle therapy;
- History of pelvic tumors;
- Simultaneous participation in other clinical studies.
Where it is running
- Nanjing Drum Tower Hospital — Nanjing, Jiangsu, China (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.