Cutaneous Biomarkers in Atopic Eczema Using a Non-Invasive Micro-Suction Device in Babies

Recruiting now

Conditions studied: Eczema, Atopic Dermatitis, Atopic Eczema

In brief

This project aims to establish whether an adapted extraction device is tolerable and will be able to measure chemical signals in baby's ISF. Insight into the chemical profiles found in the skin interstitial fluid (ISF) of healthy and diseased babies will identify signals that can be used to investigate the causes of eczema and propose new preventative strategies and effective treatments. Specifically, it aims to: 1. Demonstrate that the developed ISF device can be used to extract biomarkers from the skin of babies non-invasively and is tolerable (not causing significant discomfort, bruising, or blister formation). 2. Compare the profile of chemical markers present in the ISF of healthy babies with babies that have developed eczema. 3. Compare the biomarker levels extracted from babies with eczema in lesional and non-lesional skin using the developed ISF device. 4. Compare the microbiome and metabolome profiles from swabs taken from babies with healthy skin and with eczema in lesional and non-lesional skin (exploratory outcome).

Key facts

Study ID

NCT07228962

Run by

King's College London

People needed

30

Starts

2026-03-31

Expected to finish

2027-06-30

Last updated by the study team

2026-08-05

Who can join

Age: any, up to 1. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy babies and babies with atopic dermatitis up to 6 months old.
• Ability of parents/guardians/caregivers to provide written informed consent for study participation.
• Willingness of parents/guardians/caregivers to comply with all study requirements.
• Parents/guardians/caregivers competent use of English language.

You may not qualify if…

• Parents/guardians/caregivers unable to give informed consent.
• Preterm birth (defined as birth before 37 completed weeks gestation).
• Significant inflammatory skin disease at birth.
• Baby has any other serious health issue.

Where it is running

• St Thomas' Hospital — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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