Quantification of Calcinosis Cutis Disease Burden Using Computed Tomography Images

Recruiting now

Conditions studied: Systemic Sclerosis (SSc), Calcinosis Cutis

In brief

The main purpose of this study is to develop sensitive radiographic measurement techniques that can be used as outcome measures along with patient-reported outcome instruments in clinical trials of calcinosis cutis treatments, and potentially be used to assess disease course and treatment response in clinical practice. The goal is to test the performance of the software.

Key facts

Study ID

NCT07228429

Run by

Yale University

People needed

56

Starts

2025-10-14

Expected to finish

2026-07-01

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Scleroderma/systemic sclerosis patient with diagnosed calcinosis cutis who will be clinically treated with STS as they would in clinical SOC care
• Must be ≥ 18 years old and meet the 2013 American College of Rheumatology criteria for the diagnosis of systemic sclerosis (diffuse or limited)
• Receiving clinical care at Yale clinics

You may not qualify if…

• Unable to provide informed consent
• Currently pregnant or nursing
• Patients with a calcinosis ROI >6cm

Where it is running

• Yale Scleroderma Program — New Haven, Connecticut, United States (enrolling)

Full record on ClinicalTrials.gov

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