Fixed-Dose Combinations Pragmatic Randomized Implementation Trial for Blood Pressure Control
Starting soon · Not applicable
Conditions studied: Hypertension, Primary Care
In brief
The proposed study is an effectiveness-implementation hybrid type II trial designed to evaluate the impact of provider- and patient-directed interventions on FDC use. The trial will test the effectiveness of theory-driven nudges tailored to address provider and patient barriers. All interventions will be pharmacist-driven, with pharmacists delivering information via nudges to providers and via nudges or more intensive interventions (i.e., CPA) to patients. Data to evaluate outcomes will be extracted from electronic health records.
Key facts
- Study ID
- NCT07228065
- Run by
- Brigham and Women's Hospital
- People needed
- 720
- Starts
- 2026-07-31
- Expected to finish
- 2027-06-30
- Last updated by the study team
- 2026-06-18
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- patients with documented hypertension diagnosis
- had an elevated ambulatory blood pressure reading during the qualifying visit (systolic >140 mmHg or diastolic >90 mmHg
- have an upcoming scheduled visit
- have an active prescription for 1 blood pressure lowering medication with a fixed-dose combination (FDC) alternative
You may not qualify if…
- have received a prescription for a FDC in the preceding two years
- reside in a nursing home
- have a documented allergy to any FDC components
- are pregnant
- preferred language is not English or Spanish, defined as documentation in the EHR indicating a primary language other than English or Spanish, or a documented request for an interpreter in a language other than Spanish
- have a diagnosis of heart failure or renal failure, given that antihypertensive management in these populations typically requires disease-specific regimens and more frequent treatment adjustments
Full record on ClinicalTrials.gov
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