ESP Blocks for Posterior Spinal Fusion

Starting soon · Phase 4

Conditions studied: Postoperative Pain

In brief

This prospective randomized double-blind study evaluates the efficacy of erector spinae plane (ESP) blocks on postoperative pain in patients undergoing cervical or lumbar posterior spinal fusion. Patients will receive either 0.5% bupivacaine plus liposomal bupivacaine or 0.5% plain bupivacaine. Outcomes include opioid consumption over 72 hours, pain scores, length of stay, and time to ambulation.

Key facts

Study ID

NCT07228039

Run by

Duke University

People needed

75

Starts

2026-07-01

Expected to finish

2028-01-01

Last updated by the study team

2026-06-22

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• English speaking
• Age 18-75
• ASA physical status 1-3
• Undergoing elective cervical or lumbar posterior spinal fusion (≤3 levels)

You may not qualify if…

• Age <18 or >75
• ASA IV or V
• Non-English speaking
• BMI >40
• Opioid dependence
• Chronic pain
• Anticoagulation or coagulopathy
• Injection site infection
• Hepatic or renal insufficiency
• Allergy to study drugs
• Pregnancy
• Inability to communicate with investigators

Where it is running

• Duke University — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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