Chronic Infections and Inflammation in ME/CFS: An Observational Study

Recruiting now

Conditions studied: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

In brief

CHIIME is a study of people who have myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). People who do not have this condition will also be enrolled. Volunteers will be observed and sampled over time to identify the long-terms biological drivers and impact of their condition. The overall goal is to understand the biological and physiological mechanisms that are driving this condition.

Key facts

Study ID

NCT07227441

Run by

University of California, San Francisco

People needed

200

Starts

2026-01-01

Expected to finish

2030-09-01

Last updated by the study team

2026-03-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Willing and able to provide written informed consent
• At least 18 years of age
• Either: (1) a reported diagnosis of ME/CFS or (2) no history of ME/CFS or other infection-associated chronic conditions (healthy control)

You may not qualify if…

• Self reported or documented chronic anemia with hemoglobin <9 g/dL
• Known HIV, hepatitis B, or hepatitis C infection
• Diagnosis of an infection-associated chronic condition other than ME/CFS or Long COVID (e.g. chronic Lyme disease, post-Ebola syndrome, etc.)
• Serious medical or psychiatric illness that, in the opinion of the site investigator, would interfere with the ability to adhere to study requirements or to give informed consent
• Active drug or alcohol use or dependence that, in the opinion of the PI, would interfere with adherence to study requirements or to give informed consent

Where it is running

• Zuckerberg San Francisco General Hospital — San Francisco, California, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.