Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos

Recruiting now

Conditions studied: Complex Aneuploidy, Chaotic Aneuploidy

In brief

This study aims to evaluate the reproductive potential of embryos classified as "complex aneuploid" (involving three or more abnormal chromosomes) or "chaotic" (six or more abnormal chromosomes) through preimplantation genetic testing for aneuploidy (PGT-A). Specifically, we seek to determine whether embryos initially reported as having multiple chromosomal abnormalities might still have the potential for normal chromosomal composition, the opportunity for transfer, and ultimately, the potential to achieve a live birth through re-biopsy and reanalysis. Key Information: This portion of the study seeks your consent for the re-biopsy and genetic reanalysis of the embryos only. It does not yet include consent for potential future transfer. Participation remains completely voluntary, and your decision will not affect your current or future care. We deeply appreciate your support and commitment to advancing fertility research.

Key facts

Study ID

NCT07227116

Run by

Shady Grove Fertility Reproductive Science Center

People needed

280

Starts

2025-11-01

Expected to finish

2026-06-01

Last updated by the study team

2025-11-12

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Having ≥ 1 embryo classified as whole chromosome chaotic or complex aneuploid of 3 or more chromosomes following preimplantation genetic testing for aneuploidy using an NGS based platform Signed informed consent

You may not qualify if…

• Embryos not meeting complex/chaotic criteria Patients declining consent

Where it is running

• IVF Florida Reproductive Associates — Margate, Florida, United States (enrolling)
• Shady Grove Fertility — Atlanta, Georgia, United States (enrolling)
• Fertility Center of Illinois — Highland Park, Illinois, United States (enrolling)
• Shady Grove Fertility — Rockville, Maryland, United States (enrolling)
• Shady Grove Fertility — Towson, Maryland, United States (enrolling)
• Shady Grove Fertility — Cary, North Carolina, United States (enrolling)
• Shady Grove Fertility — Cary, North Carolina, United States (enrolling)
• Shady Grove Fertility — Chesterbrook, Pennsylvania, United States (enrolling)
• Shady Grove Fertility — Fairfax, Virginia, United States (enrolling)
• Shady Grove Fertility — Norfolk, Virginia, United States (enrolling)
• Shady Grove Fertility — Richmond, Virginia, United States (enrolling)
• SGFertility Chile Medicina Reproductiva — Santiago, Santiago Metropolitan, Chile (enrolling)

Full record on ClinicalTrials.gov

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