Non-invasive Venous Pressure Estimation
Recruiting now · Not applicable
Conditions studied: Cardiac Intensive Care
In brief
The non-invasive central venous pressure estimation in adult cardiac intensive care units (CICU) patients study is a single-center, single-arm, investigator-blinded, interventional, intra-participant comparative, feasibility study. This study aims to assess the safety and preliminary accuracy of external jugular venous occlusion pressure measured non-invasively with the venous occlusion pressure monitoring device (CPMX2) in adult CICU patients. As a feasibility study, the primary goal is to gather preliminary data on the feasibility, safety, and effectiveness of the non-invasive CVP estimation method. Although single arm, the study will compare non-invasive CVP measurements with standard invasive CVP measurements taken concurrently. This intra-participant comparative approach is essential to validate the correlation and reliability of the non-invasive method.
Key facts
- Study ID
- NCT07226479
- Run by
- Yale University
- People needed
- 40
- Starts
- 2026-01-06
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2026-01-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Provision of signed and dated informed consent
- Admitted to the CICU with invasive CVP/RA pressure monitoring placed by standard of care as determined by the treating team before enrollment
- No more than moderate TR as assessed by echocardiogram
You may not qualify if…
- Undergoing positive pressure ventilation (Bipap or invasive mechanical ventilation)
- Non-visible external jugular vein bilaterally (by visual examination or with traditional ultrasound examination)
- History of thrombosis in any of the following vessels bilaterally; external jugular vein, internal jugular vein, brachiocephalic vein or superior vena cava
- Skin lesions, vascular access sites or dressings covering neck and impeding access to the external jugular veins at the level of the muscle belly of the sternocleidomastoid muscle
Where it is running
- Yale New Haven Hospital CICU — New Haven, Connecticut, United States (enrolling)
Full record on ClinicalTrials.gov
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