The Hysterosalpingogram (HSG) Experience And Tubal Spasm (HEAT) Study

Recruiting now · Early Phase 1

Conditions studied: Infertility

In brief

The hysterosalpingogram (HSG) is the gold standard of assessing fallopian tube patency and involves the placement of a transcervical catheter to allow for instillation of radio-opaque dye into the uterine cavity and fallopian tubes which are then imaged with abdominal x-ray. A common side effect of the instillation of dye is the uterine cramping, which is both uncomfortable for the patient as well as can cause iatrogenic proximal occlusion of the fallopian tubes. Proximal tubal obstruction is often not representative of true tubal obstruction but is rather an artifact of the test. Prior studies measuring the perceived pain and cramping during HSG have been conducted which have shown reduced pain scores and decreased uterine cramping when warmed contrast dye is used. The researchers propose that the use of warmed contrast media during HSG will be correlated with decreased pain scores and fewer cases of proximal tubal occlusion in women with otherwise normal uterine anatomy.

Key facts

Study ID

NCT07226310

Run by

University of Oklahoma

People needed

240

Starts

2026-09-01

Expected to finish

2026-12-01

Last updated by the study team

2026-07-30

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women ages 18-45 undergoing tubal assessment via HSG.

You may not qualify if…

• History of fibroids
• History of pelvic inflammatory disease (PID or STD including gonorrhea, chlamydia, or trichomonas)
• History of surgically diagnosed endometriosis or suspected endometriosis on ultrasound (indicated by visualization of likely endometrioma)
• History of ectopic pregnancy or 3 or more biochemical pregnancies/pregnancy of unknown location
• History of tubal or ovarian surgery
• History of known Mullerian anomaly
• History of pelvic surgery including appendectomy
• Allergy to iodine-based contrast media
• History of prior abnormal fallopian tubes on HSG
• History of ultrasound with hydrosalpinx (unilateral or bilateral)

Where it is running

• University of Oklahoma Health Center — Oklahoma City, Oklahoma, United States (enrolling)

Full record on ClinicalTrials.gov

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