Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer

Withdrawn before enrolling · Not applicable

Conditions studied: Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Endometrial Carcinoma, Endometrial Endometrioid Adenocarcinoma, Female Reproductive System Neoplasm, Stage II Ovarian Cancer AJCC v8, Stage III Ovarian Cancer AJCC v8, Stage III Vaginal Cancer AJCC v8, Stage III Vulvar Cancer AJCC v8, Stage IV Ovarian Cancer AJCC v8, Stage IV Vaginal Cancer AJCC v8, Stage IV Vulvar Cancer AJCC v8, Triple-Negative Breast Carcinoma

In brief

This clinical trial tests feasibility, acceptability and how well a virtual mental health intervention, compared to enhanced usual care consisting of an educational intervention, works to address fear of progression for women with high risk or stage III-IV gynecologic or breast cancer. Worrying about cancer coming back or progression is natural for cancer patients. Many cancer patients face stress and uncertainty as they live longer and attend regular check-ups. A supportive program can help to develop skills to feel calmer and more resilient during uncertain times and better manage feelings of fear. The virtual mental health intervention may be a feasible, acceptable and effective may to address fear of progression for women with high risk or stage III-IV gynecologic or breast cancer.

Key facts

Study ID

NCT07226102

Run by

City of Hope Medical Center

People needed

0

Starts

2026-07-16

Expected to finish

2026-07-16

Last updated by the study team

2026-02-04

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women with stage III or IV GYN (ovarian, endometrial, cervical, vulvar/vaginal) or breast cancer who are at least 2 months from initial diagnosis
• Women with high-risk disease e.g., carcinosarcoma; ovarian cancer stage II or grade III histology; endometrioid endometrial cancer stage II or III; grade III with LVI or deep invasion; serous, clear cell or undifferentiated histologies; triple negative breast cancer
• Score ≥ 34 on the Fear of Progression Short-Form, indicating dysfunctional levels
• Age 18 or older; able to read and understand English
• Patients in remission or with progressive disease

You may not qualify if…

• Enrolled in hospice
• Major depression as assessed by patient health questionnaire (PHQ)-9
• Non-English speaking
• Prospective participants who, in the opinion of the investigator, may not be able to comply with all study procedures (including compliance issues related to feasibility/logistics)

Where it is running

• City of Hope at Arcadia — Arcadia, California, United States
• City of Hope Medical Center — Duarte, California, United States
• City of Hope at Irvine Lennar — Irvine, California, United States
• City of Hope Antelope Valley — Lancaster, California, United States
• City of Hope at Long Beach Worsham — Long Beach, California, United States
• City of Hope at Long Beach Elm — Long Beach, California, United States
• City of Hope Mission Hills — Mission Hills, California, United States
• City of Hope - Santa Clarita — Santa Clarita, California, United States
• City of Hope at Simi Valley — Simi Valley, California, United States
• City of Hope at Thousand Oaks — Thousand Oaks, California, United States
• City of Hope South Bay — Torrance, California, United States
• City of Hope Upland — Upland, California, United States

Full record on ClinicalTrials.gov

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