Accelerated High-Dose tDCS for Depression

Recruiting now · Not applicable

Conditions studied: Major Depression, Major Depression Disorders

In brief

In this study, investigators are testing whether a higher dose of a non-invasive brain stimulation technique, called transcranial direct current stimulation (tDCS), can be safely used in people with depression. Participants will come to the Brain Stimulation Lab and receive mild electrical stimulation through electrodes placed on their scalp. The study begins with a safety run-in, where the first few participants will receive stimulation at gradually increasing levels (2, 4, and 6 milliamps) while being closely monitored. If no serious side effects are found, later participants will receive repeated 6 milliamp sessions for 5 days total. Investigators will check skin comfort, mood, and overall tolerability after each session.

Key facts

Study ID: NCT07226011
Run by: Medical University of South Carolina
People needed: 20
Starts: 2025-12-15
Expected to finish: 2026-10-01
Last updated by the study team: 2026-07-13

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Ages 18-70.
Current MDD diagnosis (MINI v7).
Baseline PHQ-9 > 9.
Capacity to consent
Fluent English.

You may not qualify if…

Bipolar or psychotic disorder
Primary anxiety disorders without concomitant major depression as defined above
Current significant suicidal ideation or behaviors require a higher level of care.
Use of neuromodulation therapies (e.g., ECT, TMS, VNS) within the past 6 months.
History of seizures, implanted cranial/ cardiac metal, or neurosurgery.
Use of medications that significantly reduce seizure threshold
Frequent/severe HA
Personal history of head trauma, concussion, or TBI
Catatonic or otherwise unable to perform the consent process
Current alcohol or substance-use disorder (moderate-severe).
Any non-uniformities in the skin under the electrode site, including eczema, severe rashes, hyperhidrosis, communicable skin disorders, sensitive skin (ex. eczema, severe rashes), blisters, open wounds, burns including sunburns, cuts or irritation (e.g. due to shaving), or other skin defects or lesions, as determined by clinical personnel
Pregnancy (urine test required for women of childbearing potential).

Where it is running

MUSC Brain Stimulation Lab — Charleston, South Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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