Sex Differences in Neurobehavioral Response to THC

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Cannabis Use Disorder

In brief

This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).

Key facts

Study ID

NCT07225777

Run by

Medical University of South Carolina

People needed

40

Starts

2026-04-27

Expected to finish

2027-12-31

Last updated by the study team

2026-05-06

Who can join

Age: 21 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 21-45
• DSM-5 criteria for CUD
• Cannabis use ≥4 days/week
• THC-positive urine
• BMI 18-30
• Regular menstrual cycle (females)
• Willingness to use non-hormonal birth control (females)

You may not qualify if…

• Lifetime psychotic or bipolar disorder
• Recent drug use other than cannabis
• Current psychotropic medication
• Treatment-seeking for SUD
• Current psychiatric disorder (except mild alcohol, nicotine, or caffeine use disorder)
• Pregnancy/nursing
• MRI contraindications

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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