Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)

Recruiting now · Not applicable

Conditions studied: Fertility Preservation

In brief

HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or immediate start (without a pause).

Key facts

Study ID

NCT07225660

Run by

Shady Grove Fertility Reproductive Science Center

People needed

394

Starts

2026-02-25

Expected to finish

2027-07-01

Last updated by the study team

2026-03-02

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Ovary-bearing individuals 18 to 40 years of age.
• BMI < 40 kg/m2
• Non-smoker for at least 3 months prior to study enrollment.

You may not qualify if…

• BMI greater than or equal to 40 kg/m2
• Current Smoker
• Any contraindications to ovarian stimulation or outpatient egg retrieval under anesthesia

Where it is running

• Yale Fertility Center — Orange, Connecticut, United States (enrolling)
• Shady Grove Fertility Rockville — Rockville, Maryland, United States (enrolling)
• Reproductive Medicine Associates of New York — New York, New York, United States

Full record on ClinicalTrials.gov

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