Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia

Recruiting now · Not applicable

Conditions studied: Spinal Cord Injury Cervical, Spinal Cord Injuries (Complete and Incomplete)

In brief

The goal of this clinical trial is to learn more about how stimulating the nerves involved in sensation (either in the limbs or in the brain) can be used to restore sensation in participants who have a spinal cord injury. Participants in this study will have already been enrolled in the "Reconnecting the Hand and Arm to the Brain (ReHAB)" study, and received small electrodes in a part of the brain that is involved in sensing touch and pressure in the hand. The ReHAB study participants will also have received electrodes around the nerves in their arm. In this clinical trial, participants will receive two types of electrical stimulation: * Intracortical microstimulation (ICMS) which involves sending small electrical pulses to the part of the brain that processes sensation. * Peripheral nerve stimulation (PNS) which involves sending small electrical pulses to the nerves in the arm that transmit sensations from the hand. Researchers will try different patterns of stimulation for both ICMS and PNS and study how the participants perceive the sensations from the different stimulation patterns. The researchers will also study how combining ICMS and PNS affects the perceived sensations.

Key facts

Study ID

NCT07225582

Run by

Case Western Reserve University

People needed

3

Starts

2026-01-13

Expected to finish

2030-09-01

Last updated by the study team

2026-02-19

Who can join

Age: 22 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Enrolled in the ReHAB clinical trial and received ReHAB system components via implantation surgery.
• Willingness and availability to follow the study protocol.

You may not qualify if…

• Lack of function or operability of all implanted ReHAB system components
• Severe pain or other chronic medical condition that would prevent the participant from completing study-related activities

Where it is running

• Case Western Reserve University — Cleveland, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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