An Exosomal miRNA-based Liquid Biopsy for ICC Detection

Completed

Conditions studied: Intrahepatic Cholangiocarcinoma (Icc)

In brief

Intrahepatic cholangiocarcinoma (ICC) is a malignant liver tumor with poor prognosis and limited curative treatment options. Early and accurate detection remains an unmet clinical need. The LUMIC study aims to develop a non-invasive liquid biopsy platform based on both exosomal microRNAs (exo-miRNAs) to detect intrahepatic cholangiocarcinoma with high sensitivity and specificity.

Key facts

Study ID

NCT07225452

Run by

City of Hope Medical Center

People needed

535

Starts

2024-06-21

Expected to finish

2026-02-05

Last updated by the study team

2026-03-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age ≥ 18 years
• Histologically confirmed intrahepatic cholangiocarcinoma
• Availability of pre-treatment plasma sample
• Informed consent provided

You may not qualify if…

• Extrahepatic cholangiocarcinoma
• History of other malignancy within 5 years
• Active infection, autoimmune disease, or pregnancy
• Inadequate clinical data or poor sample quality

Where it is running

• City of Hope Medical Center — Duarte, California, United States

Full record on ClinicalTrials.gov

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