Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment
Starting soon · Not applicable
Conditions studied: Mild Cognitive Impairment (MCI)
In brief
The goal of this one-arm clinical trial is to determine whether participants with mild cognitive impairment (MCI) can successfully navigate a virtual reality (VR) maze. The VR maze is designed as a training tool aimed at improving participants' spatial navigation abilities. Main Aims: 1. To determine whether at least 70% of older adults enrolled in the study can complete twenty-four 50-minute training sessions over a 4-month period. 2. To assess whether combining virtual reality with EEG recordings can be used to measure brain activation and changes in brain activation associated with spatial navigation learning. Participants will: 1. Walk in an open, unobstructed space while wearing VR goggles. 2. Explore up to fifty different virtual mazes in sequence and attempt to find their way through each one.
Key facts
- Study ID
- NCT07225400
- Run by
- Albert Einstein College of Medicine
- People needed
- 30
- Starts
- 2026-10-01
- Expected to finish
- 2027-12-23
- Last updated by the study team
- 2026-08-10
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 65 and older with amnestic mild cognitive impairment (aMCI);
- Can speak English;
- Agrees to MoBI recording;
- Normal or corrected-to-normal vision/audition;
- Able to walk unassisted for 10 minutes;
- Plan to be in the area for next year
You may not qualify if…
- Dementia (Memory Impairment/AD8 screen);
- Medical conditions that affect participation such as vertigo and neck pain;
- Hospitalization in the past six months or plans for surgery affecting participation in the next four months;
- Mobility limitations solely due to musculoskeletal limitation or pain;
- Terminal illness with life expectancy less than 12 months;
- Presence of clinical disorders that overtly alter attention like delirium;
- Active psychoses or psychiatric symptoms;
- Living in nursing home;
- Participation in intervention trial;
- Standard contraindications to EEG including seizure medication, epilepsy, stroke, traumatic brain injury;
- Pregnant women
Where it is running
- Albert Einstein College of Medicine — The Bronx, New York, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.